My favorite thing about being a part of the MCB program is that it keeps me in touch with a diverse group of colleagues. It facilitates discussions across departments on campus which otherwise might rarely interact. As a new student, having the freedom to do rotations in practically any lab across campus without departmental borders was really nice. My current research is focused on Paired-like homeodomain transcription factor 2 (Pitx2), a homeobox transcription factor essential for the development of various organs including the heart, lungs and muscles. Homozygous mutants die between embryonic day 10 and 14, with the most striking phenotype being an open abdominal wall. Thus my work has been to construct developmental networks using technologies such as microarray's, chip-qPCR and chip-seq to identify what genes are regulated by Pitx2.
Joseph Beckman-When Copper Meets SOD: An ALS Story
The Linus Pauling Institute has some very exciting research to report on potential therapies for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease. Using a mouse model of ALS, Dr. Joseph Beckman and his colleagues in Australia and the United Kingdom have shown that a copper compound, called CuATSM, delayed the onset of symptoms and extended lifespan (Read More).
Pankaj Jaiswal-The genome of Eucalyptus grandis article published in Nature
Eucalypts are the world’s most widely planted hardwood trees. Their outstanding diversity, adaptability and growth have made them a global renewable resource of fibre and energy. We sequenced and assembled >94% of the 640-megabase genome of Eucalyptus grandis (Read More).
Pankaj Jaiswal-Genome could unlock eucalyptus potential for paper, fuel, and fiber
In a collaboration spanning five continents, scientists have announced the complete sequencing of one of the world’s most widely planted trees, Eucalyptus grandis (Read More).
Pankaj Jaiswal lab leads study that sequences diploid Einkorn wheat
Common bread wheat with a genome that is ~5 times the size of the human genome is a hexaploid, with three times more number of chromosomes compared to ancestral diploid genomes (Read More).
Mark Leid-OSU breakthrough in cancer research
Researchers are optimistic for future cancer therapies after a breakthrough in cancer research at Oregon State University (Read More).
Brett Tyler recognized by People's Republic of China for highest civic award for non-Chinese scientists
The People's Republic of China recognized Brett Tyler, CGRB Director and Botany & Plant Pathology Professor for his achievements with its highest civic award for non-Chinese scientists (Read More)
Andrey Morgun's team is part of efforts to develop treatment for women infected with HPV
Researchers at OSU, working with scientists around the world, have discovered a potential screening tool for diagnosing cervical cancer and determining the best avenues for treatment (Read More)
Pankaj Jaiswal's lab research on Wikipathways for plants
A community pathway curation portal and case study in rice and arabidopsis seed development networks (Read More)
Wikipathways for plants: an online community portal for plant pathway curation and analysis (Read More)
Pankaj Jaiswal's lab research on genome scale metabolic network for rice
Accompanying analysis of tryptophan, auxin and serotonin biosynthesis regulation under biotic stress (Read More)
Stephen Giovannoni's paper on the abundant SAR11 viruses in the ocean
Published in Nature on 21 February 2013 (Read More)
Jaiswal lab assembles the transcriptome of a noxious weed Brachypodium sylvaticum
Scientists from Oregon State University and Portland State University develop the transcriptome and other genetic resources of an invasive plant, Brachypodium sylvaticum, for extensive research on plant adaptation. (Read More)
Joseph Beckman part of study that may hold key to new drugs
OSU research helps shed light on cell death in ALS, other diseases (Read More)
Wolpert lab publishes research paper "Tricking the Guard: Exploiting Plant Defense for Disease Susceptibility"
Typically, pathogens deploy virulence effectors to disable defense. Plants defeat effectors with resistance proteins that guard effector targets. We found that a pathogen exploits a resistance protein by activating it to confer susceptibility in Arabidopsis. (Read More)
Chrissa Kioussi is a co-author on the study of advances in regenerative medicine and developmental biology
A group of researchers in Israel, the United States and other nations have made important advances in the rapidly-expanding field of "regenerative medicine," outlining for the first time connections in genetic regulation that normally prevent birth defects in heart and facial muscles. (Read More).
Jaiswal and OSU to study what goes on inside the cells of corn and rice
Oregon State University has been named a partner on a $10 million grant that aims to further the understanding of the molecular interactions and genes in crops that include rice and cord (Read More).
Gombart worked on research on Vitamin B3
Vitamin B3 could be the new weapon in the fight against superbugs such as MRSA, researchers have suggested. (Read More)
Denver lab discovers selfish DNA in animal mitochondria
August 9, 2012: Researchers at Oregon State University have discovered, for the first time in any animal species, a type of “selfish” mitochondrial DNA that is actually hurting the organism and lessening its chance to survive – and bears a strong similarity to some damage done to human cells as they age. (Read More)
Jaiswal lab co-leads on poplar gene research with federal support
An Oregon State University effort to identify genes that help poplar trees grow in marginal land received a $1.4 million boost from the U.S. Department of Energy and Office of Biological and Environmental Research on 7/25/2012. (Read More)
Can Antivirulence Drugs Stop Infections Without Causing Resistance?
Brett Mellbye and Martin Schuster from Oregon State University carried out laboratory simulations to determine the effect antivirulence drug-resistant strains could have on therapy. (Read More)
Researchers discover "partners in crime" in deadly skin disease
Tracking the path of this deadly cancer takes a pharmaceutical partnership. Two OSU scientists are finding clues to how we can stop skin cells from going awry.
Disruption of Biological Clocks Causes Neurodegeneration, Early Death
New research at Oregon State University provides evidence for the first time that disruption of circadian rhythms – the biological “clocks” found in many animals – can clearly cause accelerated neurodegeneration, loss of motor function and premature death. (Read More)