Education
Ph.D. 1993, University of Pennsylvania
Research
The initial intracellular response to many external stimuli, including hormones, growth factors, and neurotransmitters, involves activation of a membrane phospholipid-hydrolyzing enzyme, phospholipase C-ß (PLC-ß) whose product second messengers mobilize intracellular calcium and activate protein kinase C (PKC) leading to a wide variety of cellular responses. Among these responses are normal processes such as smooth muscle (e.g. blood vessel) contraction, neurotransmitter release and stimulation of cell growth. Howeer, too much PLC-ß signaling correlates with enlarged atria in mice and humans with heart valve disease and atrial fibrillation. Too little PLC-ß seems to predispose cells to malignancies including leukemia, lymphoma and skin tumors. We are seeking to understand the means by which PLC-ß activity is regulated intracellularly in normal and disease states as a means of identifying new targets for therapeutic agents. To this end, my laboratory utilizes biochemical, molecular biology, and cell biology techniques to study PLC-ß function and regulation.
