Office: 403 Pharmacy Building
Phone: (541) 737-8047
MD, Kharkiv Medical University, Ukraine
PhD, Federal University of Sao Paulo (UNIFESP), Brazil
Postdoctoral training at NIAID and NIH
KEYWORDS: Systems Biology, Systems Medicine, Pharmacogenomics, Network analysis, Host-microbe interaction, Cancer, Transplantation, Immunogenetics
I have studied biological questions ranging from how transplant rejection can be detected and discriminated from infection, to how commensal bacteria communicate with the immune system, which particular transcription factor regulates a given function, to the tumor/virus/host interaction that causes the cellular switch from benign to malignant cervical cancer. What ties all these together is a systems approach. In each case, my goal was to address a specific medically and/or biologically meaningful question by applying large scale tools to measure as many characteristics as possible without pre-existing biases; then to analyze the data by a variety of methods, and to follow up with further study. In these studies, I used a top-down approach, spanning a multitude of different scales and techniques, varying from molecular/genetic analysis of human diseases to in vivo and in vitro analysis of mouse models. I used both established algorithms and developed new ones for analysis of large-scale biological data. Recently, I started using the concept and tools of inference of causality from observational data approaching this by network analysis. I am by nature a collaborative researcher. All of the research projects that I have been involved in (as a team member or a team leader) were highly collaborative, frequently with people from different areas (professional mathematicians, bioinformatics specialists, a wide variety of medical doctors, microbiologists, endocrinologists, immunologists and molecular biologists).